It is Keika chan.
Not not,,
Ha!
"I have fallen asleep on a pheasant."
"Do not wake me, already!"
Yayoi, sorry.
Well, yesterday, I brought Concep 1/4 tablet, which had been prescribed before, to animal hospital and I had you switch back to 1/8 tablets.
Keika-chan was also on visit February 20, 2019
Keika-chan is the epileptic seizure after a long absence! February 12, 2019
With this, I plan to have only 1/6 tablets out next time.
By the way, results were obtained at the previous visit,
Conceive blood concentration was here.
Since I had it investigated with great difficulty, I examined oneself about antiepileptic drugs and blood concentration afterwards.
It was about human medicine examined, but unfortunately I did not know about cats.
I would like to summarize again as I can find out about cats.
*Note*
I gathered this information personally and summarized.
It is not responsible for diagnostic treatment and accuracy.
For individual diseases please consult with your hospital etc on your own.
First of all, Keika-chan is drinking,
Zonisamide (ZNS)
This zonisamide is the "common name" of medicine.
Coneve or Epirez is a "product name" attached to each company. Even though it is the same medicine, both names are confusing. Concep is DS Pharma Animal Health, Epiless is Kyoritsu Pharmaceutical selling it with a name, respectively.
If you are a human you get a prescription on the prescription with a generic name and you can say "change to generic", you are asked to get a guy who is a pharmacy, but the animal hospital treats it at each animal hospital It seems that medicine will come out.
By the way, if it's for human beings, it seems that Kyowa Medicine is issued under the name of Xonisamide "Amel" by Dainippon Sumitomo Pharma in the name of Excegran. Recently it seems that it is being used as a medicine for Parkinson (human beings). (Dainippon Sumitomo Pharmaceutical's Treasuref)
Here zonisamide,
In the case of a human, the first day 100 mg - 200 mg. Afterwards it will increase and use up to 600 mg a day.
For children, first 2-4 mg / kg per day. It seems that it is 12 mg / kg maximum a day.
If I apply this to Keika chan,
Weight is 3.1 kg.
First 5 mg 2 times, Next 6.25 mg 2 times, then 7.292 mg 2 times.
One day per kg, 3.225 mg, 4.032 mg, 4.704 mg, respectively.
Is it about the first amount in human beings, now?
Effective blood concentration, as shown in the picture above,
10-30 μg / ml
It has become.
However, depending on the book, "Effects and side effects often appear regardless of blood concentration" and measurement seems to be a guide.
Side effects include sleepiness, rash, loss of appetite, limb numbness, urinary calculus and so on.
It seems that sleepiness and appetite decrease are not present for now, but urinary calculus is troubling.
Continued,
Diazepam (DZP)
It is a medicine you use when you are suffering from Keika-chan, having you take out with a die-up supplement. It is out of Takada Seiyaku. If it is a human child, since 0.4 - 0.5 mg / kg is inserted into the rectum and it is up to 1 mg / kg per day, if it is weight of Keika-chan (3.1 kg), it is over with 4 mg per one, Is it half of 2 mg?
It is also used as a medicine for epilepsy, but as a human being, it is used as a benzodiazepine type anxiolytic drug, neurosis or depression. It is long-acting type long-lasting medicine.
In tablets with syrup for injection, suppositories and medicines with various shapes, epilepsy is used for injection etc. when seizures do not stop. Suppositories are used especially for children with febrile convulsions. It is because children are hard to inject.
Besides the die-up product name, Celsin, Horizon etc.
For die-up suppositories, it is 0.4-0.5 mg / kg once in children. Maximum 1 mg / kg per day
In the case of Keika chan 3.1 kg and 2 mg so it is quite a lot.
Effective blood concentrations,
200-500 μg / ml poisoning area 1000 μg / ml or more
It has become.
Side effects include drowsiness, dizziness, dizziness, nausea and vomiting. It seems that respiratory depression and dependence will occur when used in large quantities.
then,
I have not used it for Keika-chan yet,
Antiepileptic drugs that may possibly be used,
Sodium valproate (VPA)
This is the first-line drug of tonic-clonic seizures (in the case of humans).
Tonic to clonic seizures is a type of epileptic seizure, suddenly lost consciousness, collapsed, crushed limbs after crimping limbs, causing seizures, seems to be this, also Katsura-chan.
There was a movie of easy-to-understand epileptic seizure (animation), so I will introduce ↓
Animation 13 representative cases of epileptic seizure
It is on sale under the product name of Kyowa Hakko Kirin to Depaken, Dainippon Sumitomo Pharma to Vallerin. (In addition, Tanabe Mitsubishi Pharma to Serenica etc.)
This is also a medicine used relatively earlier, tablets, fine grains, syrup and a variety of ways to drink.
It is also used to suppress migraine attacks and manic depressive illnesses.
Effective blood concentrations,
50-100 μg / ml
Side effects include drowsiness, weight gain, gastrointestinal disorders, etc. Then when using it during pregnancy the probability of fetal malformation will increase. (Although Keika-chan does not matter)
I do not want to think too much, but if Keika-chan does not recover from spasm with zonisamide, there may be times when thinking of using valproic acid as another medicine.
For epilepsy, 400 to 1200 mg per day
I examined three kinds of antiepileptic drugs for the time being.
However, this is the case for people, so I'd like to examine the case of cats a bit more.
Because people are different from cats, hey.
Results of blood collection by Keika-chan and mama - Inspection value of human · Inspection value of cat - February 15, 2019
I would like to introduce other medicines, if there are opportunities as well.
Well then, good night.
Keika - chan is no longer diving. . .
original Japanese version → 抗てんかん薬（ゾニサミド・ジアゼパム・バルプロ酸）と血中濃度について調べました 2019年2月26日
