Thursday, February 28, 2019

Keika-chan also got some medicine in epileptic seizures! ! February 27, 2019



When thinking that I studied antiepileptic drug yesterday,
I investigated anti-epileptic drug (zonisamide / diazepam / valproic acid) and blood concentration     February 26, 2019


this morning,
Keika-chan,
she had an epileptic seizure - ー 😭


We only had medicine increased - ー ー ー ー ー ー

桂花ちゃん新しい病院でコンセーブに変わりました
Keika-chan is the epileptic seizure after a long absence!    February 12, 2019
Keika-chan was also on visit      February 20, 2019







I think that it is hard to understand because it is a screenshot of a video, but she is cramping the body and body.
It was about 30 seconds in all.

The time is at 7:44 am.
Mommy is (of course) the time to prepare to go out with work.

I put a suppository in it and saw a little about it, but somewhat, my back legs fluttered and sitting and it did not move and the appearance was strange.
After all I thought whether I will be late for work and take her to the hospital and I'm calling "I will be late as I go to the (cats) hospital" at my work place. (It is not a lie but guilt feeling ,,,,)

I thought about entering an animal hospital just at 9 o'clock ,,,
Diarrhea pea after coma ,,
Diarrhea Pee a lot in her ass. .

Rampage trying to catch and wipe to the floor ,,,
Even in corrugated cardboard, stuck in cardboard ,,



This corrugated house is already disposed of.
Although it was her favorite that endured moving ,,,
Thank you for your hard work.
Let's make it again. .


In a hurry, wipe the butt with some wet tissue and dash to the animal hospital.
I arrived after 9:10,
Then wait for 1 hour 10 minutes ,,,

Well, I told you to go at 10 o'clock - ー
Even though there are plans that can not be rid of by all means at 11 o'clock-----

I was frustrated and irritated in the waiting room where nobody was gone, confirmed to the woman of the reception "How much more?", Finally it was called to explain the circumstances to the veterinarian, asking for closeness during the day and dashing to the workplace Did.

Whew. ,,

After all this time, I feel a sense of shortage of manpower.


The work which seemed to be over at 5 o'clock was such a sudden correspondence entered at 4:30 pm, after 6 o'clock, it managed to slide into the animal hospital until 7 o'clock. (It is secret that I ran backward through the way)

The wobble of the foot improved much better, but the food of the meal was not satisfactory as it seems sleepy.
Her medicine will increase again.



Concept has increased to half tablets. 12.5 mg twice a day.
25 mg in one day.
Is 8.064 mg per kg body weight so it is quite obvious.
If drowsiness comes out, adjustment becomes necessary,
I was told to keep them because 1/6, 1/8 we had before before may still be used for adjustment.
It is prescription for 10 days for the time being.



The die-up suppositories are now 6 mg in size, which means that 1/3 of them are used once.

1/3 suppository ??




Here, is this feeling? What?



At least, 5704 yen.




Even after we return, she is not very well.



Sometimes she licks after wiping the girls.
The hair is getting wet and solidified somehow. .
I was told to the veterinarian to stop the shower for a while and I do not wear it as much as I wipe it, so I wipe it while watching the situation.



As expected after all, rice



Eating is bad ,,,



she just slept.



So I switched Chu-ru in to this place.



Hat,



she is eating and eating.







It is a state in the Chu-ru festival.
It was nice, for the time being, even eating only Chu-ru.



By the way, the usual dinner soup,



she do not need it ;;;
She looked like she wanted more, but hey. .


There is a difficult instruction that veterinarians should not be hot or cold,
Is it left to air conditioner for a while?


I do not know the cause of diarrhea.
I also thought that I used olive oil with suppository, but I was OK at the beginning of the girls' neck, and because there was diarrhea in the second half, I wonder if they are different. .
Because it was cold last night?

After all seizures are a lot of impression on the turn of the season, in the case of Keika chan.
There is not midsummer or midwinter, September, May June, the end of February.





Let's go to the hospital again in the day after tomorrow.

Tomorrow is also your mother's job, what shall I do, I can not rest tomorrow, I am worried. .

original Japanese version → 桂花ちゃんまたてんかん発作でお薬増えました!!  2019年2月27日

Wednesday, February 27, 2019

I investigated anti-epileptic drug (zonisamide / diazepam / valproic acid) and blood concentration February 26, 2019




It is Keika chan.




Not not,,



Ha!



"I have fallen asleep on a pheasant."



"Do not wake me, already!"

Yayoi, sorry.



Well, yesterday, I brought Concep 1/4 tablet, which had been prescribed before, to animal hospital and I had you switch back to 1/8 tablets.
Keika-chan was also on visit      February 20, 2019
Keika-chan is the epileptic seizure after a long absence!    February 12, 2019
With this, I plan to have only 1/6 tablets out next time.

By the way, results were obtained at the previous visit,
Conceive blood concentration was here.



Since I had it investigated with great difficulty, I examined oneself about antiepileptic drugs and blood concentration afterwards.
It was about human medicine examined, but unfortunately I did not know about cats.
I would like to summarize again as I can find out about cats.


*Note*
I gathered this information personally and summarized.
It is not responsible for diagnostic treatment and accuracy.
For individual diseases please consult with your hospital etc on your own.



First of all, Keika-chan is drinking,

Zonisamide (ZNS)

This zonisamide is the "common name" of medicine.
Coneve or Epirez is a "product name" attached to each company. Even though it is the same medicine, both names are confusing. Concep is DS Pharma Animal Health, Epiless is Kyoritsu Pharmaceutical selling it with a name, respectively.
If you are a human you get a prescription on the prescription with a generic name and you can say "change to generic", you are asked to get a guy who is a pharmacy, but the animal hospital treats it at each animal hospital It seems that medicine will come out.
By the way, if it's for human beings, it seems that Kyowa Medicine is issued under the name of Xonisamide "Amel" by Dainippon Sumitomo Pharma in the name of Excegran. Recently it seems that it is being used as a medicine for Parkinson (human beings). (Dainippon Sumitomo Pharmaceutical's Treasuref)

Here zonisamide,
In the case of a human, the first day 100 mg - 200 mg. Afterwards it will increase and use up to 600 mg a day.
For children, first 2-4 mg / kg per day. It seems that it is 12 mg / kg maximum a day.

If I apply this to Keika chan,
Weight is 3.1 kg.
First 5 mg 2 times, Next 6.25 mg 2 times, then 7.292 mg 2 times.
One day per kg, 3.225 mg, 4.032 mg, 4.704 mg, respectively.
Is it about the first amount in human beings, now?

Effective blood concentration, as shown in the picture above,
10-30 μg / ml
It has become.

However, depending on the book, "Effects and side effects often appear regardless of blood concentration" and measurement seems to be a guide.

Side effects include sleepiness, rash, loss of appetite, limb numbness, urinary calculus and so on.
It seems that sleepiness and appetite decrease are not present for now, but urinary calculus is troubling.

Continued,

Diazepam  (DZP)

It is a medicine you use when you are suffering from Keika-chan, having you take out with a die-up supplement. It is out of Takada Seiyaku. If it is a human child, since 0.4 - 0.5 mg / kg is inserted into the rectum and it is up to 1 mg / kg per day, if it is weight of Keika-chan (3.1 kg), it is over with 4 mg per one, Is it half of 2 mg?



It is also used as a medicine for epilepsy, but as a human being, it is used as a benzodiazepine type anxiolytic drug, neurosis or depression. It is long-acting type long-lasting medicine.
In tablets with syrup for injection, suppositories and medicines with various shapes, epilepsy is used for injection etc. when seizures do not stop. Suppositories are used especially for children with febrile convulsions. It is because children are hard to inject.

Besides the die-up product name, Celsin, Horizon etc.

For die-up suppositories, it is 0.4-0.5 mg / kg once in children. Maximum 1 mg / kg per day

In the case of Keika chan 3.1 kg and 2 mg so it is quite a lot.

Effective blood concentrations,
200-500 μg / ml     poisoning area 1000 μg / ml or more
It has become.

Side effects include drowsiness, dizziness, dizziness, nausea and vomiting. It seems that respiratory depression and dependence will occur when used in large quantities.


then,
I have not used it for Keika-chan yet,
Antiepileptic drugs that may possibly be used,

Sodium valproate  (VPA)

This is the first-line drug of tonic-clonic seizures (in the case of humans).
Tonic to clonic seizures is a type of epileptic seizure, suddenly lost consciousness, collapsed, crushed limbs after crimping limbs, causing seizures, seems to be this, also Katsura-chan.
There was a movie of easy-to-understand epileptic seizure (animation), so I will introduce ↓
Animation 13 representative cases of epileptic seizure

It is on sale under the product name of Kyowa Hakko Kirin to Depaken, Dainippon Sumitomo Pharma to Vallerin. (In addition, Tanabe Mitsubishi Pharma to Serenica etc.)
This is also a medicine used relatively earlier, tablets, fine grains, syrup and a variety of ways to drink.
It is also used to suppress migraine attacks and manic depressive illnesses.

Effective blood concentrations,
50-100 μg / ml

Side effects include drowsiness, weight gain, gastrointestinal disorders, etc. Then when using it during pregnancy the probability of fetal malformation will increase. (Although Keika-chan does not matter)

I do not want to think too much, but if Keika-chan does not recover from spasm with zonisamide, there may be times when thinking of using valproic acid as another medicine.

For epilepsy, 400 to 1200 mg per day

I examined three kinds of antiepileptic drugs for the time being.
However, this is the case for people, so I'd like to examine the case of cats a bit more.
Because people are different from cats, hey.
Results of blood collection by Keika-chan and mama - Inspection value of human · Inspection value of cat -      February 15, 2019

I would like to introduce other medicines, if there are opportunities as well.

Well then, good night.



Keika - chan is no longer diving. . .


original Japanese version → 抗てんかん薬(ゾニサミド・ジアゼパム・バルプロ酸)と血中濃度について調べました  2019年2月26日

Tuesday, February 26, 2019

A little thin too? Weight measurement February 25, 2019



It is Shion-chan.



"Is not it cool?



You are a bit conscious, do not you?


Well today, we measured the weight of Shion-chan and Mokuren-chan.



By way of example, we are measuring in a very primitive way that mommy hugs cats, weighs their weights, and draws their mothers.




Indeed,
Today's result is! ! !

Dadada Dada,

Darn!


Shion-chan   5.5 kg ← 5.7 kg ← 5.95 kg ← 5.8 kg ← 5.9 kg

Mokuren-chan   3.45 kg ← 3.65 kg ← 3.51 kg ← 3.8 kg ← 3.75 kg


They are losing weight, both of them! !

Perhaps it is too thin? What? Because it is two and a half months between last time and this time. .

I guess it's OK to keep on with this.


 

"Even so!"



"Loooooook, this smart body!"

Yes it is, it is beautiful.




"I also tried hard and I lost weight."



"Hang in there"



Mokuren-chan was also great.
You became a beautiful woman.


After all the body is small, just by slightly increasing or decreasing the rice, the weight gains and decreases gently.
It is just a little bit.
It is difficult, adjustment ,,,


Huh?
Have you lost weight?

Well, I can not lose weight at all.
I mean rather fat one.

It has been decided that the current state of work as busy continues next year. .
My salary will not go up, the consumption tax will go up, I will not even feel like feeling with stress.
It is after all the year that it took a long time to catch a cold and to recover. Whew. ,,
I drink a lot of alcohol or eat ice cream, I will relieve stress, do not have any other fun ,,,




"What excuses you !! Let's do it better !!!"

Well?
Angry Mokuren-chan? What? What?



"People who are saying that ,,,



This way! "



"Punishment!"










I am sorry ,, I do not complain any more, so would you please come down? .

Mommy also exchanges my mind and will try hard on diet ,,


No good?



original Japanese version  → ちょっと痩せすぎ?体重測定  2019年2月25日




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